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Structure activity relationship study of marine bromotyrosine derivatives as anti-biofilm compounds

KACOU Alain Biofilms & Antifouling - Molecular Aspects of the inhibition of marine Biofilms (MAIB)

Beginning: November 2015
Defense: December 12th, 2019

Supervisor: BLACHE Yves
Co-supervisor: YAPI Ange Désiré


Biofilms are structures communities of bacterial cells protected by a self-polymeric matrix and adherent to an inert or a living surface. They cause many problem, among them:

To fight against biofilms and reduce their impact on human activities, developing new antibiofilm agents could be a solution. Previous studies have shown that Bromotyrosines, marine substances extracted from marine sponges with anti-biofilm activities, could be a base to have anti-biofilms hemi-synthetic molecules with 1,2,3-triazole moiety, particularly hemibastadin derivatives.

Objectives of this thesis are :

Laboratoire MAPIEM (EA 4323) - http://mapiem.univ-tln.fr/Structure-activity-relationship-study-of-marine-bromotyrosine-derivatives-as.html - mapiem@univ-tln.fr