Structure activity relationship study of marine bromotyrosine derivatives as anti-biofilm compounds
Supervisor: BLACHE Yves
Co-supervisor: YAPI Ange Désiré
Biofilms are structures communities of bacterial cells protected by a self-polymeric matrix and adherent to an inert or a living surface. They cause many problem, among them:
- Biofouling in marine environment, increasing fuel consumption and material damages
- Resilience and resistance against antibiotics, persistent and chronic infections are other major problems, particularly in medical sector.
To fight against biofilms and reduce their impact on human activities, developing new antibiofilm agents could be a solution. Previous studies have shown that Bromotyrosines, marine substances extracted from marine sponges with anti-biofilm activities, could be a base to have anti-biofilms hemi-synthetic molecules with 1,2,3-triazole moiety, particularly hemibastadin derivatives.
Objectives of this thesis are :
- Study structure activity relationships of hemibastadin derivatives
- Identify the mechanism of anti-biofilm action
- Evaluate the capacity of this molecules to make synergy with antibiotics and/or biocides molecules