Laboratoire MAPIEM (EA 4323)

Research Topics

Organic chemistry, antibiofilm and antifouling compounds, Quorum Sensing, biofilm

Scientific Productions:

Publications :

2020

• - Biofilms and Antifouling - MAIB
  Hayek Mahmoud, Baraquet Claudine, Lami Raphaël, Blache Yves, Molmeret Maëlle
  The marine bacterium Shewanella woodyi produces C8-HSL to regulate bioluminescence
  Microb. Ecol. (2020) 79(4), 865-881

2019

• - Biofilms and Antifouling - MAIB
  Andjouh Sofyane, Blache Yves
  Screening of bromotyramine analogues as antifouling compounds against marine bacteria
  Biofouling . 2016 Sep;32(8):871-81.
• - Biofilms and Antifouling - MAIB
  Gozoua Emmanuel, Koffy-Nevry Rose, Blache Yves
  Biofilm formation in marine bacteria and biocidal sensitivity: interplay between a potent antibiofilm compound (AS162) and quorum-sensing autoinducers
  3 Biotech . 2019 Sep;9(9):338.
• - Biofilms and Antifouling - MAIB
  Kacou Alain, Ouvrard Axel, Jamet Dominique, Jamet Jean-Louis, Blache Y.
  Towards eco-friendly biocides: preparation, antibiofilm activity of hemibastadin analogues
  Lett Appl Microbiol . 2019 Apr;68(4):360-368.
• - Biofilms and Antifouling - MAIB
  A Praud‐Tabariès, O Bottzeck, Y Blache
  Synthesis of Lamellarin Q analogues as potential antibiofilm compounds
  Journal of Heterocyclic Chemistry 56 (4), 1458-1463, 2019

2018

• - Biofilms and Antifouling - MAIB
  Sall Cheikh, Ayé Mireille, Bottzeck Olivier, Praud Annie, Blache Yves
  Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria
  Bioorganic & medicinal chemistry letters (2018) 28 (2), 155-159

2017

• - Biofilms and Antifouling - MAIB
  Sall Cheikh , Ndoye Samba Fama, Seck Matar ,Valentin Alexis and Blache Yves
  Influence of Substituents on the Antiplasmodial and Cytotoxic Activities of 5-chloro-3,4-dihydro-1Hpyrano[3,4-b]-1,10-phenanthrolinone as Antimalarial Agent
  International Journal of Tropical disease & Health (2017) 22(1): 1-7.

2016

• - Biofilms and Antifouling - AFS - MAIB
  Andjouh Sofyane, Bressy Christine, Blache Yves
  RAFT polymerization of Bromotyramine-based 4-acryloyl-1,2,3- triazole: A Functional Monomers and Polymers Family through Click Chemistry
  RCS Advances (2016) 6(18), 14496-14504.
• - Biofilms and Antifouling - MAIB
  Linares Denis, Jean Natacha, Van Overtvelt Perrine, Ouidir Tassadit, Hardouin Julie, Blache Yves, Molmeret Maëlle
  The marine bacteria Shewanella frigidimarina NCIMB400 up-regulates the type VI secretion system during early biofilm formation
  Environmental Microbiology Reports (2016) 8(1), 110-121.
• - Biofilms and Antifouling - MAIB - MCEB
  Ben Hsouna Anis, Saoudi Mongi, Culioli Gérald, Blache Yves, Ghlissi Zohra, Chaabane Rim, El Feki Abdelfattah, Jaoua Samir, Trigui Mohamed
  Protective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver
  Toxicology and Industrial Health (2016) 32(4), 694-706.
• - Biofilms and Antifouling - MAIB - MCEB
  Brian-Jaisson Florence, Molmeret Maëlle, Fahs Armand, Guentas-Dombrowsky Linda, Culioli Gérald, Blache Yves, Cérantola Stéphane, Ortalo-Magné Annick
  Characterization and anti-biofilm activity of extracellular polymeric substances produced by the marine biofilm-forming bacterium Pseudoalteromonas ulvae strain TC14
  Biofouling (2016) 32(5), 547-560.

2015

• - MAIB
  Andjouh Sofyane, Blache Yves
  Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies
  Bioorganic & Medicinal Chemistry Letters (2015) 25(24), 25-24.
• - Biofilms and Antifouling - MAIB - MCEB
  Aye Mireille, Bonnin-Jusserand Maryse, Brian-Jaisson Florence, Ortalo-Magné Annick, Culioli Gérald, Koffi Nevry Rose, Rabah Nadia, Blache Yves, Molmeret Maëlle
  Modulation of violacein production and phenotypes associated with biofilm by exogenous quorum sensing N-acylhomoserine lactones in the marine bacterium Pseudoalteromonas ulvae TC14
  Microbiology (2015) 161(10), 2039-2051.

2014

• - Biofilms and Antifouling - AFS - MCEB
  Camps Mercedes, Barani Aude, Gregori Gérald, Bouchez Agnès, LeBerre Brigitte, Bressy Christine, Blache Yves, Briand Jean-François
  Antifouling coatings influence both abundance and community structure of colonizing biofilms: A case study in the North-Western Mediterranean Sea
  Applied Environmental Microbiology (2014) 80(16), 8421-8431.
• - Biofilms and Antifouling - MAIB - MCEB
  Brian-Jaisson Florence, Ortalo-Magné Annick, Guentas-Dombrowsky Linda, Armougom Fabrice, Blache Yves, Molmeret Maëlle
  Identification of bacterial strains isolated from the Mediterranean Sea exhibiting different abilities of biofilm formation
  Microbial Ecology (2014) 68(1), 94-110.
• - Biofilms and Antifouling - MAIB - MCEB
  Othmani Ahlem, Bouzidi Naïma, Viano Yannick, Alliche Zahia, Seridi Halima, Blache Yves, El Hattab Mohamed, Briand Jean-François, Culioli Gérald
  Anti-microfouling properties of compounds isolated from several Mediterranean Dictyota spp.
  Journal of Applied Phycology (2014) 26(3), 1573-1584.

2013

• - Biofilms and Antifouling - MAIB - MCEB
  Salta Maria, Wharton Julian, Blache Yves, Stokes Keith, Briand Jean-François
  Marine biofilms on artificial surfaces: structure and dynamics
  Environmental Microbiology (2013) 15, 2879-2893.
• - Biofilms and Antifouling - MAIB
  Praud-Tabariès Annie, Bottzeck Olivier, Blache Yves
  Synthesis of polymerizable vinyltriazoles: Development of an optimized one-pot strategy starting from 4-bromobutyne
  Green Chemistry (2013) 5(15), 1138-1141.
• - Biofilms and Antifouling - MAIB
  Pacquelet Sandrine, Blache Yves, Tan Kimny, Lacaille-Dubois Marie-Aleth, Desbois Nicolas
  A convenient synthesis of heterocyclic compounds with dihydropyrano[3,4-b]pyridine scaffold
  Synthetic Communications (2013) 43(8), 1092-1100.

2012

• - Biofilms and Antifouling - AFS - MAIB - MCEB
  Briand Jean-François, Djeridi Ikram, Jamet Dominique, Coupé Stéphane, Bressy Christine, Molmeret Maëlle, Le Berre Brigitte, Rimet Frederic, Bouchez Agnès, Blache Yves
  Pioneer marine biofilms on antifouling paints immersed in two contrasted French Mediterranean coast sites
  Biofouling (2012) 28(5), 453-463.
• - Biofilms and Antifouling - MAIB
  Bouyer Florence, Moretto Johnny, Pertuit David, Szollosi Anna, Lacaille-Dubois Marie-Aleth, Blache Yves, Chauffert Bruno, Desbois Nicolas
  Synthesis, cytotoxicity and structure-activity relationships between ester and amide functionalities in novel acridine-based platinium(II) complexes
  Journal of Inorganic Biochemistry (2012) 110, 51-57.
• - Biofilms and Antifouling - MAIB - MCEB
  Kilani-Feki Olfa, Zouari Imen, Culioli Gérald, Ortalo-Magné Annick, Zouari Nabil, Blache Yves, Jaoua Samir
  Correlation between synthesis variation of 2-alkylquinolones and the antifungal activity of a Burkholderia cepacia strains collection
  World Journal of Microbiology & Biotechnology (2012) 28(1), 275-281.

2011

• - Biofilms and Antifouling - MAIB
  Linares Denis, Bottzeck Olivier, Pereira Olivier, Praud-Tabaries Annie, Blache Yves
  Designing 2-aminoimidazole alkaloids analogues with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles
  Bioorganic and Medicinal Chemistry Letters (2011) 21, 6751-6755.
• - Biofilms and Antifouling - MAIB - MCEB
  Penez Nicolas, Culioli Gérald, Perez Thierry, Briand Jean-François, Thomas Olivier P., Blache Yves
  Antifouling properties of simple indole and purine alkaloids from the mediterranean gorgonian Paramuricea clavata
  Journal of Natural Products (2011) 74(10), 2304-2308.
• - Biofilms and Antifouling - MAIB - MCEB
  Camps Mercedes, Briand Jean-François, Guentas-Dombrowsky Linda, Culioli Gérald, Bazire Alexis, Blache Yves
  Antifouling activity of commercial biocides vs natural and natural-derived products assessed by marine bacteria adhesion bioassay
  Marine Pollution Bulletin (2011) 62(5), 1032-1040.
• - MAIB - MCEB
  Kilani-Feki Olfa, Culioli Gérald, Ortalo-Magné Annick, Zouari Nabil, Blache Yves, Jaoua Samir
  Environmental Burkholderia cepacia strain Cs5 acting by two analogous alkyl-quinolones and a didecyl-phthalate against a broad spectrum of phytopathogens fungi
  Current Microbiology (2011) 62(5), 1490-1495.
• - Biofilms and Antifouling - MAIB
  Sall Cheikh, Guentas-Dombrowsky Linda, Bottzeck Olivier, Praud-Tabaries Annie, Blache Yves
  Targeting bacterial biofilms: design of a terpenoid-like library as non-toxic anti-biofilm compounds
  Bioorganic & Medicinal Chemistry Letters (2011) 21(5), 1493-1497.
• - Biofilms and Antifouling - MAIB - MCEB
  Viano Yannick, Bonhomme Dominique, Ortalo-Magné Annick, Thomas Olivier P., El Hattab Mohamed, Piovetti Louis, Blache Yves, Culioli Gérald
  Dictyotadimer A, a new dissymmetric bis-diterpene from a brown alga of the genus Dictyota
  Tetrahedron Letters (2011) 52(9), 1031-1035.
• - Biofilms and Antifouling - MAIB - MCEB
  Ben Hsouna Anis, Trigui Mohamed, Culioli Gérald, Blache Yves, Jaoua Samir
  Antioxidant constituents from Lawsonia inermis leaves: Isolation, structure elucidation and antioxidative capacity
  Food Chemistry (2011) 125(1), 193-200.
• - Biofilms and Antifouling - MAIB
  Andjouh Sofyane, Blache Yves
  Parallel synthesis of a bis-triazoles library as psammaplin A analogues: A new wave of antibiofilm compounds?
  Bioorg Med Chem Lett . 2019 Feb 15;29(4):614-618.

Conferences and communications :

• - COM National - Biofilms and Antifouling - MAIB
  Blache Yves
  Nature inspires chemistry : smart anti-biofilm molecules to reduce environmental impact of antifouling coatings
  12ème journée scientifique de l’ISM2, 2 juillet 2019.
• - COM International - Biofilms and Antifouling - MAIB
  Blache Yves
  Bio-inspired compounds for smart antibiofilm compounds
  Faculté de Pharmacie d’Abidjan, 10 Janvier 2019
• - COM National - Biofilms and Antifouling - MAIB
  Kacou Alain, Yapi A.D., Blache Yves
  Nouvelles molécules anti-biofilm: étude des relations structure-activité d’analogues d’hémibastadines
  Journées SCF, avril 2018, Marseille.
• - COM National - Biofilms and Antifouling - MAIB
  Blache Yves
  Toward bioinspired anti-biofilm strategies: a green solution to reduce enviromental impact of antifouling coatings
  2émes Journées Italo-Francaises de Nanosciences, 31 janvier 2018
• - COM National - Biofilms and Antifouling - MAIB
  Blache Yves
  Sea business & innovation
  2nd COST-MARISTEM Meeting, Observatoire Océanologique Banyuls-sur-Mer, 27-30 novembre 2018
• - COM International - Biofilms and Antifouling - MAIB
  Gozoua Emmanuel, Molmeret Maëlle, Baraquet Claudine, Blache Yves
  Modulation of the toxic phase of antibiofilm compounds on Pseudoalteromonas ulvae (TC14) by interfering with quorum sensing
  BioMicroWorld Conference, Madrid, Spain, 2017
• - COM International - Biofilms and Antifouling - MAIB
  Harb Manar, Blache Yves, Molmeret Maëlle, Baraquet Claudine
  Biofilm formation and signaling of c-di-GMP in Shewanella oneidensis
  BioMicroWorld Conference, Madrid, Spain, 2017
• - COM International - Biofilms and Antifouling - MAIB
  Blache Yves, Andjouh Sofiane, Bottzeck Olivier, Praud Annie
  Towards smart biocide-free antifouling strategies against marine bacteria : design of marine natural products analogues
  BioMicroWorld Conference, Madrid, Spain, 2017.
• - COM International - Biofilms and Antifouling - AFS - MCEB
  Bazire Alexis, Blache Yves, Blériot Laurent, Bressy Christine, Briand Jean-François, Copin Dalyal, Culioli Gérald, Delbury Maxime, Dufossé Laurent, Faÿ Fabienne, Grondin Isabelle, Linossier Isabelle, Mangrie Ludovic, Réhel Karine, Sauleau Pierre, Taye Thierry, Tunin-Ley Alina, Turquet Jean, Zéa Abando Claudia, Zubia Mayalen
  Tropical microalgae isolated on Reunion island (France, Indian ocean) as sources of antifouling molecules: The BIOPAINTROP project
  17th European Congress on Biotechnology, Krakow (Pologne), juillet 2016.
• - AFF International - Biofilms and Antifouling - AFS - MCEB
  Bazire Alexis, Blache Yves, Blériot Laurent, Bressy Christine, Briand Jean-François, Copin Dalyal, Culioli Gérald, Delbury Maxime, Dufossé Laurent, Faÿ Fabienne, Grondin Isabelle, Linossier Isabelle, Mangrie Ludovic, Réhel Karine, Sauleau Pierre, Taye Thierry, Tunin-Ley Alina, Turquet Jean, Zéa Abando Claudia, Zubia Mayalen
  Tropical microalgae isolated on Reunion island (France, Indian Ocean) as sources of antifouling molecules: The BIOPAINTROP project
  18th International Congress on Marine Corrosion and Fouling, Toulon (France), juin 2016.
• - AFF International - Biofilms and Antifouling - MAIB
  Harb Manar, Kacou Alain, Blache Yves, Molmeret Maëlle, Baraquet Claudine
  Biofilm formation and c-di-GMP signaling in marine environment
  18th International Congress on Marine Corrosion and Fouling, Toulon (France), juin 2016.
• - AFF International - Biofilms and Antifouling - MAIB
  Hayek Mahmoud, Baraquet Claudine, Blache Yves, Molmeret Maelle
  Characterization of Shewanella woodyi Quorum Sensing systems
  18th International Congress on Marine Corrosion and Fouling, Toulon (France), juin 2016.
• - COM International - Biofilms and Antifouling - MAIB
  Ayé Mireille, Baraquet Claudine, Molmeret Maëlle, Blache Yves
  Inhibition of violacein production in marine bacteria Pseudoalteromonas ulvae TC14 by quorum sensing inhibitors
  18th International Congress on Marine Corrosion and Fouling, Toulo n (France), juin 2016 (Oral communication)
• - INV - Biofilms and Antifouling - MAIB
  Blache Yves
  Targeting biofilms with non-toxic molecules: a green solution for reduced environmental impact of the use of biocides
  Nanotechnology for Water Treatment and Solar Energy Applications, Musscat (Oman), décembre 2015.
• - COM National - Biofilms and Antifouling - MAIB - MCEB
  Brian-Jaisson Florence, Molmeret Maëlle, Fahs Armand, Guentas-Dombrowsky Linda, Culioli Gérald, Blache Yves, Cérantola Stéphane, Ortalo-Magné Annick
  Caractérisation et activité anti‐biofilm de substances polymériques extracellulaires produites par la bactérie marine Pseudoalteromonas ulvae (TC14)
  7ème Colloque du Réseau National Biofilms (RNB), Toulouse (France), décembre 2015.
• - INV - Biofilms and Antifouling - MAIB
  Blache Yves
  Molécules bio-inspirées pour la lutte antibiofilm en milieu marin
  BIOADH 2015, Beni Mellal (Maroc), mai 2015.
• - AFF National - Biofilms and Antifouling - MAIB
  Andjouh Sofyane, Blache Yves
  Synthèse et criblage biologique d’analogues d’alcaloïdes de type bromotyrosine comme inhibiteurs de biofilm bactérien
  24ème Journée de la Chimie Société Chimique de France-PACA, Toulon (France), avril 2015.
• - INV - Biofilms and Antifouling - MAIB
  Blache Yves
  Lutte antibiofilm: Des plantes médicinales aux analogues de produits naturels
  3èmes Journées Scientifiques de l’Agro-Alimentaire, Hammamet (Tunisie), mars 2015.
• - COM International - Biofilms and Antifouling - MAIB
  Andjouh Sofyane, Blache Yves
  Synthesis and antibiofilm activity of bromotyramines analogues
  7th JFIC-GIFC, Turin (Italie), mai 2014.
• - INV - Biofilms and Antifouling - MAIB
  Blache Yves
  Lutte antibiofilm:de la médecine traditionnelle aux analogues de produits naturels
  5ème symposium international des plantes aromatiques et médicinales, Marrackech (Maroc), novembre 2013.
• - COM International - Biofilms and Antifouling - AFS - MAIB - MCEB
  Anton Charlène, Camps Mercedes, Romain Davy, Couteau Sandra, Tanguy Brigitte, Horatius Lydia, Culioli Gérald, Briand Jean-François, Blache Yves, Quiniou Françoise, Compère Chantal, Bressy Christine
  Antifouling activity of natural active compounds through bioassays and field immersion tests
  40th CIESM Congress, Marseille (France), octobre 2013.
• - COM National - Biofilms and Antifouling - MAIB - MCEB
  Othmani Ahlem, Molmeret Maëlle, Blache Yves, Bouchez Agnes, Briand Jean-François, Culioli Gérald
  Médiation chimique entre l’algue brune méditerranéenne Taonia atomaria et la communauté bactérienne associée à sa surface
  6ème Colloque d’Ecologie Microbienne, Parent (France), octobre 2013.
• - AFF International - Biofilms and Antifouling - MAIB - MCEB
  Brian-Jaisson Florence, Ortalo-Magné Annick, Molmeret Maëlle, Guentas-Dombrowsky Linda, Blache Yves
  Extracellular polymeric substances from a marine biofilm forming strain, Pseudoalteromonas ulvae TC14. Characterization of exopolysaccharides and antibiofilm activity
  International Polysaccharide Conference EPNOE, Nice (France), octobre 2013.
• - COM International - Biofilms and Antifouling - MAIB - MCEB
  Othmani Ahlem, Molmeret Maëlle, Blache Yves, Briand Jean-François, Culioli Gérald
  Interactions between macro-algae and associated bacteria: biofilm control by surface secondary metabolites in the Mediterranean brown seaweed Taonia atomaria
  40th CIESM Congress, Marseille (France), octobre 2013.
• - AFF National - Biofilms and Antifouling - AFS - MCEB
  Urvois Felix, Gregory Gerald, Rehel Karine, Bouchez Agnes, Garnier Cedric, Barani Aude, Le Berre Brigitte, Le Poupon Christophe, Bressy Christine, Blache Yves, Briand Jean-François
  Variations spatio-temporelles de communautés microbiennes de biofilms colonisant des revêtements antifouling en méditerranée et dans l’Océan Atlantique
  6ème Colloque d’Ecologie Microbienne, Parent (France), octobre 2013.
• - COM International - Biofilms and Antifouling - MAIB
  Blache Yves
  Targeting greener antifouling solutions : from natural products to synthetic anti-biofilm leads
  Biomicroworld 2013, Madrid (Spain), septembre 2013.
• - AFF International - Biofilms and Antifouling - AFS - MCEB
  Urvois Felix, Gregory Gerald, Rehel Karine, Bouchez Agnes, Garnier Cedric, Barani Aude, Le Berre Brigitte, Le Poupon Christophe, Bressy Christine, Blache Yves, Briand Jean-François
  Spatio-temporal variation of the marine biofilm communities colonizing antifouling coatings in the Mediterranean Sea vs the Atlantic Ocean
  13th Symposium on Aquatic Microbial Ecology, Stresa (Italy), septembre 2013.
• - AFF International - Biofilms and Antifouling - MCEB
  Othmani Ahlem, Molmeret Maëlle, Ortalo-Magné Annick, Blache Yves, Briand Jean-François, Culioli Gérald
  What about the ability of the Mediterranean brown seaweed Taonia atomaria to control foulers but also to select surface-associated bacteria?
  XIVth International Symposium on Marine Natural Products (MaNaPro 2013) & 8th European Conference on Marine Natural Products (ECMNP), La Toja (Spain), septembre 2013.
• - COM National - Biofilms and Antifouling - MAIB - MCEB
  Othmani Ahlem, Molmeret Maëlle, Ortalo-Magné Annick, Blache Yves, Briand Jean-François, Culioli Gérald
  Médiation chimique entre l’algue brune méditerranéenne Taonia atomaria et la communauté bactérienne associée à la surface
  1ère Rencontre Nationale des Jeunes Chercheurs en Écologie Chimique, Montpellier (France), juin 2013.
• - AFF National - Biofilms and Antifouling - MCEB
  Othmani Ahlem, Meert Madaline, Molmeret Maëlle, Blache Yves, Briand Jean-François, Culioli Gérald
  Analyse du métabolome de surface de l’algue brune Taonia atomaria et étude de son implication dans le contrôle du biofilm bactérien
  23ème Journée de la Chimie SCF-PACA, Nice (France), avril 2013.
• - COM International - Biofilms and Antifouling - MAIB
  Van Overvelt Perrine, Linares Denis, Jean Natacha, Blache Yves, Molmeret Maëlle
  How Shewanella frigidimarina adheres and forms a biofilm on inert surfaces?
  Eurobiofilms, Ghent, Belgique, 2013

Book Chapters :

• - Biofilms and Antifouling - MAIB
  Cheikh Sall1, Insa Seck, Samba Fama Ndoye, Matar Seck, Alexis Valentin, and Yves Blache
  Contribution in the Malaria Control of Substituted 5- chloro-3,4-dihydro-1H-pyrano[3,4-b]-1,10- phenanthrolinone Compounds: Antiplasmodial and Cytotoxic Activities
  Current Trends in Disease and Health Vol. 1, chap 7, 2019

Patents :

• - Biofilms and Antifouling - Durability and Functional Materials - MAIB - ACS
  S. Andjouh, F. Perrin, Y. Blache
  Bis-triazole compounds with anti-biofilm and anti-corrosion properties
  WO 2017/102883 A1, US Patent 10,487,0711, 2019
• - Biofilms and Antifouling - Durability and Functional Materials
  Andjouh Sofiane , Perrin François-Xavier , Blache Yves
  Bis-triazoles compounds with antibiofilm and anticorrosion properties
  WO 2017/102883 A1
• - Biofilms and Antifouling - Durability and Functional Materials - MAIB - ACS
  Andjouh Sofyane, Perrin François-Xavier, Blache Yves
  Bis-triazoles compounds with anti-biofilm and anti-corrosion properties
  (2015) PCT/FR/2015/053492.

2009

• - Biofilms and Antifouling - MAIB - MCEB
  Trigui Mohamed, Ben Hsouna Anis, Zouari Nabil, Culioli Gérald, Blache Yves, Jaoua Samir
  Isolement et caractérisation des activités biologiques de deux nouvelles molécules biologiquement actives ainsi que d’extraits organiques à partir de la plante Lawsonia inermis LBPes03
  Laboratoire des Biopesticides (Centre de Biotechnologies de Sfax, Tunisie) - Laboratoire MAPIEM (Université de Toulon), (2009) TN/2009/0420.